Calculate AUC for intravenous dosing

Source: R/auciv.R

Calculate AUC for intravenous dosing

pk.calc.auciv(conc, time, c0, auc, ..., options = list(), check = TRUE)

pk.calc.auciv_pbext(auc, auciv)

Arguments

conc

Measured concentrations

time

Time of the measurement of the concentrations

c0

The concentration at time 0, typically calculated using pk.calc.c0()

auc

The AUC calculated using conc and time without c0 (it may be calculated using any method)

...

For functions other than pk.calc.auxc, these values are passed to pk.calc.auxc

options

List of changes to the default PKNCA options (see PKNCA.options())

check

Run assert_conc_time(), clean.conc.blq(), and clean.conc.na()?

auciv

The AUC calculated using c0

Value

pk.calc.auciv: The AUC calculated using c0

pk.calc.auciv_pctbackextrap: The AUC percent back-extrapolated

Details

The AUC for intravenous (IV) dosing extrapolates the AUC back from the first measurement to time 0 using c0 and the AUC calculated by another method (for example the auclast).

The calculation method takes the following steps:

  • time = 0 must be present in the data with a measured concentration.

  • The AUC between time = 0 and the next time point is calculated (auc_first).

  • The AUC between time = 0 with c0 and the next time point is calculated (auc_second).

  • The final AUC is the initial AUC plus the difference between the two AUCs (auc_final <- auc + auc_second - auc_first).

The calculation for back-extrapolation is 100*(1 - auc/auciv).

Functions

  • pk.calc.auciv_pbext(): Calculate the percent back-extrapolated AUC for IV administration