Pre-processes data Computes QTcB, QTcF, deltaQTcF, deltaQTcB, deltaHR, deltaQTcB Baseline Mean, deltaQTcF Baseline Mean, deltaHR Baseline Mean

Pre-processes data Computes QTcB, QTcF, deltaQTcF, deltaQTcB, deltaHR, deltaQTcB Baseline Mean, deltaQTcF Baseline Mean, deltaHR Baseline Mean

preprocess(
  data,
  qt_col = QT,
  qtbl_col = QTBL,
  rr_col = RR,
  rrbl_col = RRBL,
  hr_col = HR,
  hrbl_col = HRBL,
  qtcf_col = QTCF,
  qtcfbl_col = QTCFBL,
  qtcb_col = QTCB,
  qtcbbl_col = QTCBBL,
  id_col = ID,
  deduplicate = TRUE
)

Arguments

data

A data frame containing C-QT analysis dataset

qt_col

An unquoted column name for QT measurements

qtbl_col

An unquoted column name for baseline QT measurements

rr_col

An unquoted column name for RR measurements

rrbl_col

An unquoted column name for baseline RR measurements

hr_col

An unquoted column name for HR measurements, HR by default

hrbl_col

An unquoted column name for baseline HR measurements, HRBL by default

qtcf_col

An unquoted column name for QTCF measurements, QTCF by default

qtcfbl_col

An unquoted column name for baseline QTCF measurements, QTCFBL by default

qtcb_col

An unquoted column name for QTCB measurements, QTCB by default

qtcbbl_col

An unquoted column name for baseline QTCB measurements, QTCBBL by default

id_col

An unquoted column name for subject ID

deduplicate

Boolean, whether baseline values are duplicated over rows. If true duplicates will be removed from average

Value

dataframe with deltas computed from BL

Examples

preprocess(cqtkit_data_verapamil)
#> # A tibble: 643 × 30
#>       ID TRTG   DOSE DOSEU DOSEF  NTLD TAFD   CONC CONCU    RR  RRBL    HR  HRBL
#>    <dbl> <fct> <dbl> <chr> <fct> <dbl> <chr> <dbl> <chr> <dbl> <dbl> <dbl> <dbl>
#>  1  1001 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     968   851   62.0  70.5
#>  2  1002 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA    1097. 1193.  54.7  50.3
#>  3  1003 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA    1026.  923.  58.5  65.2
#>  4  1004 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     862.  883.  69.6  68.0
#>  5  1005 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA    1060. 1126.  56.6  53.3
#>  6  1006 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     998   999   60.2  60.2
#>  7  1007 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     919.  909   65.4  66.1
#>  8  1008 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     827.  991   72.5  60.6
#>  9  1009 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     872.  798.  68.9  75.3
#> 10  1010 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA    1070. 1071   56.1  56.0
#> # ℹ 633 more rows
#> # ℹ 17 more variables: HRBLM <dbl>, deltaHRBL <dbl>, QT <dbl>, QTBL <dbl>,
#> #   QTCB <dbl>, QTCBBL <dbl>, QTCBBLM <dbl>, deltaQTCBBL <dbl>, QTCF <dbl>,
#> #   QTCFBL <dbl>, QTCFBLM <dbl>, deltaQTCFBL <dbl>, deltaQTCB <dbl>,
#> #   deltaQTCF <dbl>, deltaRR <dbl>, deltaHR <dbl>, deltaQT <dbl>