Internal Helper: Encode below-the-limit-of-quantification (BLQ) values as -Inf

Vectorized helper used in VPC pre-processing. Replaces BLQ-flagged positions of x with -Inf. A position is BLQ when any of the following hold: is.na(x), !is.null(loq) && x < loq, or !is.null(mdv) && mdv == 1. Returns the modified vector — quantile computation is performed downstream.

Usage

var_loqcens(x, loq = NULL, mdv = NULL, call = rlang::caller_env())

Arguments

x

Numeric vector to encode.

loq

Numeric scalar or vector of length length(x) giving the lower limit of quantification, or NULL (no < loq trigger).

mdv

Integer/logical vector of length length(x) flagging missing-DV rows (NONMEM convention MDV == 1), or NULL (no MDV trigger).

call

The call reported in errors.

Value

Numeric vector the same length as x, with BLQ positions set to -Inf.

Examples

pmxhelpr:::var_loqcens(c(1, 2, 5, NA, 10), loq = 3, mdv = c(0, 0, 0, 0, 1))
#> [1] -Inf -Inf    5 -Inf -Inf
pmxhelpr:::var_loqcens(c(1, 2, 5), loq = NULL, mdv = c(0, 1, 0))
#> [1]    1 -Inf    5