rats.RdRat treatment data from Mantel et al. Three rats were chosen from each of 100 litters, one of which was treated with a drug, and then all followed for tumor incidence.
rats
data(cancer, package="survival")| litter: | litter number from 1 to 100 |
| rx: | treatment,(1=drug, 0=control) |
| time: | time to tumor or last follow-up |
| status: | event status, 1=tumor and 0=censored |
| sex: | male or female |
N. Mantel, N. R. Bohidar and J. L. Ciminera. Mantel-Haenszel analyses of litter-matched time to response data, with modifications for recovery of interlitter information. Cancer Research, 37:3863-3868, 1977.
E. W. Lee, L. J. Wei, and D. Amato, Cox-type regression analysis for large number of small groups of correlated failure time observations, in "Survival Analysis, State of the Art", Kluwer, 1992.
Since only 2/150 of the male rats have a tumor, most analyses use only females (odd numbered litters), e.g. Lee et al.