Simulate PK data from a 1-compartment iv model — pk_iv_1cmt • vpc

Simulate PK data from a 1-compartment iv model

pk_iv_1cmt(
  t,
  t_inf = 1,
  tau = 24,
  dose = 120,
  CL = 0.345,
  Vc = 1.75,
  ruv = NULL
)

Arguments

t: Time after dose
t_inf: Infusion length
tau: Dosing interval
dose: Dose
CL: Clearance
Vc: Volume of distribution
ruv: Residual variability

Value

A vector of predicted values, with or without added residual variability

Examples

dat1 <- vpc:::pk_iv_1cmt(t = c(0:72), tau = 24, dose = 120, 
                   CL = 5, Vc = 50)
dat2 <- vpc:::pk_iv_1cmt(t = c(0:72), tau = 24, dose = 120, 
                   CL = 5, Vc = 50, 
                   ruv = list(proportional = 0.1, additive = 0.1))