Design dose-reponse trials

Mods() getResp() plotMods() plot(<Mods>)

Define dose-response models

guesst()

Calculate guesstimates based on prior knowledge

optContr() plot(<optContr>) plotContr()

Calculate optimal contrasts

optDesign() calcCrit() rndDesign() plot(<DRdesign>)

Function to calculate optimal designs

planMod() summary(<planMod>) plot(<planMod>)

Evaluate performance metrics for fitting dose-response models

powMCT()

Calculate power for multiple contrast test

sampSize() sampSizeMCT() targN() powN() plot(<targN>)

Sample size calculations

DesignMCPModApp()

Start externally hosted DesignMCPMod Shiny App

Analyze dose-response trials

MCPMod() predict(<MCPMod>) plot(<MCPMod>)

MCPMod - Multiple Comparisons and Modeling

MCTpval()

Calculate multiplicity adjusted p-values for multiple contrast test

MCTtest()

Performs multiple contrast test

bMCTtest()

Performs Bayesian multiple contrast test

critVal()

Calculate critical value for multiple contrast test

mvpostmix()

Prior to posterior updating for a multivariate normal mixture

mvtnorm.control()

Control options for pmvt and qmvt functions

Fit dose-response model

bFitMod() coef(<bFitMod>) predict(<bFitMod>) plot(<bFitMod>)

Fit a dose-response model using Bayesian or bootstrap methods.

defBnds()

Calculates default bounds for non-linear parameters in dose-response models

emax() emaxGrad() sigEmax() sigEmaxGrad() exponential() exponentialGrad() quadratic() quadraticGrad() betaMod() betaModGrad() linear() linearGrad() linlog() linlogGrad() logistic() logisticGrad() linInt() linIntGrad()

Built-in dose-response models in DoseFinding

fitMod() coef(<DRMod>) vcov(<DRMod>) predict(<DRMod>) plot(<DRMod>) logLik(<DRMod>) AIC(<DRMod>) gAIC(<DRMod>)

Fit non-linear dose-response model

maFitMod() predict(<maFit>) plot(<maFit>)

Fit dose-response models via bootstrap model averaging (bagging)

TD() ED()

Calculate dose estimates for a fitted dose-response model (via fitMod, bFitMod) or maFitMod) or a Mods object

Datasets

biom

Biometrics Dose Response data

glycobrom

Glycopyrronium Bromide dose-response data

IBScovars

Irritable Bowel Syndrome Dose Response data with covariates

migraine

Migraine Dose Response data

neurodeg

Neurodegenerative disease simulated longitudinal dose-finding data set