Calvert equation for carboplatin

Source: R/calc_carboplatin_calvert.R

The Calvert equation calculates a dose expected to bring the patient to the target AUC given their glomerular filtration rate (GFR). The original equation was developed on a data set of 18 individuals with GFR of 33-136 ml/min.

calc_carboplatin_calvert(target_auc, gfr = NULL, ...)

Arguments

target_auc

target AUC, in mg/ml-min, typically between 2-8 mg/ml-min

gfr

glomerular filtration rate, in ml/min. See also `clinPK::calc_egfr`.

...

arguments passed on to `calc_egfr` if gfr is not supplied

Examples

calc_carboplatin_calvert(5, 100)
#> [1] 700
calc_carboplatin_calvert(4, 30)
#> [1] 224
calc_carboplatin_calvert(2, sex = "male", age = 50, scr = 1.1, weight = 70)
#> Creatinine unit not specified, assuming mg/dL.
#> [1] 230.9091