Anthropomorphic equations |
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Calculate body surface area |
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Calculate fat-free mass |
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Calculate BMI |
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Calculate ideal body weight in kg for children and adults |
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Calculate lean body weight |
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Calculate adjusted body weight (ABW) |
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Calculate commonly used "dosing weight" |
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Calculate baseline sCr |
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Percentile weight for age for children |
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Percentile height for age for children |
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Percentile BMI for age for children |
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Clinical chemistry |
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Calculate eGFR |
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Calculate eGFR based on Cystatin C measurements |
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Calculate kinetic GFR |
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Estimate serum creatinine |
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Estimate serum creatinine in neonates |
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Calculate AKI stage |
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Calculate neutropenia grade from ANC |
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Conversions |
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Convert kg to lbs |
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Convert lbs to kg |
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Convert kg to oz |
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Convert oz to kg |
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Convert any weight unit to kg |
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Convert cm to inch |
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Convert inch to cm |
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Convert concentration to molar |
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Convert molar to concentration |
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Convert quantity expressed in absolute units relative to normalized BSA |
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Convert quantity expressed relative to BSA to absolute units |
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Convert flow (e.g. clearance) from / to units |
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Convert albumin from / to units |
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Convert serum creatinine from various assays to Jaffe |
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Convert creatinine to different unit |
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Convert bilirubin from / to units |
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PK compartmental equationsFunctions to simulate concentrations for linear PK models. |
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Concentration predictions for 1-compartmental PK model after single or multiple bolus doses |
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Concentration predictions for 2-compartmental PK model with infusion dosing at steady state |
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Cmin (trough) for linear 1-compartment PK model at steady state |
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Cmax for linear 1-compartment PK model at steady state |
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Concentration predictions for 2-compartmental PK model, single or multiple infusions |
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Concentration predictions for 2-compartmental PK model with infusion dosing at steady state |
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Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state |
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Cmax (trough) for 2-compartmental PK model, bolus dosing at steady state |
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Concentration predictions for 1-compartmental PK model after single or multiple bolus doses |
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Concentration predictions for 1-compartmental PK model with bolus dosing at steady state |
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Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing |
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Cmax for linear 1-compartment PK model at steady state, bolus dosing |
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Calculate terminal half-life for 1-compartment model |
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Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses |
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Concentration predictions for 2-compartmental PK model, single or multiple bolus doses |
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Concentration predictions for 2-compartmental PK model, bolus dosing at steady state |
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Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state |
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Cmax for 2-compartmental PK model, bolus dosing at steady state |
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Calculate half-life(s) for 2-compartment model |
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Calculate average half-life for 2-compartment model during a specific interval |
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PK steady state equations |
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Calculate accumulation ratio This is the ratio of drug concentration or AUC at steady state over concentrations after single dose |
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Calculate fraction of steady state at particular time after start of dosing |
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Time to steady state In either time units or number of doses |
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Dose/TDM calculationsFunctions to calculate the dose expected to achieve a specific target exposure. |
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Calculate dose to achieve steady state trough for 1-compartmental PK model with infusion dosing at steady state |
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Calculate dose to achieve steady state trough for 1-compartmental PK model bolus dosing at steady state |
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Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state |
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Calculate dose to achieve steady state trough for 2-compartmental PK model bolus dosing at steady state |
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Calculate dose to achieve steady state Cmax for 1-compartmental PK model with infusion dosing at steady state |
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Calculate dose to achieve steady state Cmax for 1-compartmental PK model bolus dosing at steady state |
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Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state |
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Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state |
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Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model |
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Convert dose to expected AUCinf or AUCt for 1 compartment linear PK model |
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Convert AUCtau or AUCt to dose (for 1-compartment linear PK model) |
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Miscellaneous functions |
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Perform an NCA based on a NONMEM-style dataset |
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Returns parameters needed to calculate eGFR according to the method specified. |
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Checks whether required covariates for eGFR calculations are present |
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Calvert equation for carboplatin |
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Calculate elimination rate when given a single TDM sample |
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Calculate elimination rate when given two TDM samples |
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Calculate half-life based on two points |
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Calculate the amounts in all compartments in a compartmental PK system based on a given concentration in the central compartment, and assuming steady state. |
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Generic function to calculate the dose nearest to a specific dose unit increment |
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Generic function to calculate the interval nearest to a possible dosing interval |
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Read WHO growth tables |
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Valid units |
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Add residual variability to data |