Calculate elimination rate when given two TDM samples

Calculate elimination rate when given two TDM samples

calc_kel_double_tdm(
  dose = 1000,
  t = c(2, 11.5),
  dv = c(30, 10),
  tau = 12,
  t_inf = 1,
  V = NULL,
  steady_state = TRUE,
  return_parameters = FALSE
)

Arguments

dose

dose amount

t

time or time after dose, vector of size 2

dv

observed value, vector of size 2

tau

dosing interval

t_inf

infusion time

V

if specified, use that (empiric) value and don't estimate from data. Default `NULL`.

steady_state

samples taken at steady state? Only influences AUCtau.

return_parameters

return all parameters instead of only kel?

Examples

calc_kel_double_tdm(dose = 1000, t = c(3, 18), dv = c(30, 10))
#> [1] 0.07324082