Calculate the kinetic GFR based on a patients first two serum creatinine measurements. Kinetic GFR may be more predictive of future AKI for patients whose serum creatinine is changing quickly. Briefly, an increase in SCr over the course of a day indicates an effective GFR lower than the most recent SCr measurement may indicate if steadystate is assumed, while a decrease in SCr over a short time indicates a higher effective GFR than the most recent SCr would indicate. There are several ways of approximating maximum theoretical creatinine accumulation rate; here the method used by Pianta et al., (PLoS ONE, 2015) has been implemented.
calc_kgfr(
scr1 = NULL,
scr2 = NULL,
scr_unit = "mg/dl",
time_delay = NULL,
weight = NULL,
vd = NULL,
egfr = NULL,
egfr_method = NULL,
sex = NULL,
age = NULL,
height = NULL,
...
)baseline scr
second scr measurement
scr unit, defaults to mg/dl
time between scr1 and scr2 in hours
patient weight in kg
volume of distribution in L, defaults to 0.6 * weight
eGFR in ml/min at the time of scr1, or leave blank to call calc_egfr
string, only necessary if egfr is not specified.
string (male or female), only necessary if egfr is not specified.
age in years, only necessary if egfr is not specified.
in m, necessary only for some egfr calculation methods.
further arguments (optional) to be passed to calc_egfr.
kGFR, in ml/min
calc_kgfr(weight = 100, scr1 = 150, scr2 = 200, scr_unit = 'umol/l',
time_delay = 24, egfr = 30)
#> [1] 23.2
calc_kgfr(weight = 70, scr1 = 350, scr2 = 300, scr_unit = 'umol/l',
time_delay = 24, egfr_method = 'mdrd', age = 70, sex = 'male')
#> [1] 27.73687