Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state — pk_2cmt_inf_cmin_ss • clinPK

Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state

pk_2cmt_inf_cmin_ss(
  dose = 100,
  tau = 12,
  t_inf = 1,
  CL = 3,
  V = 30,
  Q = 2,
  V2 = 20,
  ruv = NULL
)

Arguments

dose: dose
tau: dosing interval
t_inf: infusion time
CL: clearance
V: volume of central compartment
Q: inter-compartimental clearance
V2: volume of peripheral compartment
ruv: residual error (list)

Examples

pk_2cmt_inf_cmin_ss(
  dose = 1000, tau = 12, t_inf = 2,
  CL = 5, V = 50, Q = 20, V2 = 200)
#> [1] 13.06368