Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state

Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state

pk_2cmt_inf_dose_from_cmin(
  cmin = 1,
  tau = 12,
  t_inf = 1,
  CL = 3,
  V = 30,
  Q = 2,
  V2 = 20
)

Arguments

cmin

desired trough concentration

tau

dosing interval

t_inf

infusion time

CL

clearance

V

volume of distribution

Q

inter-compartimental clearance

V2

volume of peripheral compartment

Examples

dos <- pk_2cmt_inf_dose_from_cmin(
  cmin = 10, tau = 12, t_inf = 2,
  CL = 5, V = 50, Q = 20, V2 = 200)
find_nearest_dose(dos, 100)
#> [1] 800