compute_grouped_mean_sd.Rdcomputes a the mean and standard deviation of the dependent variable data in DV_col grouped by time and dose.
compute_grouped_mean_sd(
data,
dv_col,
ntime_col,
dose_col,
group_col = NULL,
reference_dose = NULL,
conf_int = 0.95
)A data frame containing C-QT analysis dataset
An unquoted column name for dependent variable
An unquoted column name for the Time group
An unquoted column name for dose group
An unquoted column of optional grouping column
Reference dose value for comparison calculations
Numeric confidence interval level (default: 0.9)
a dataframe of the dv averaged over the grouped time and dose
data_proc <- preprocess(cqtkit_data_verapamil)
data_proc <- dplyr::mutate(data_proc, DOSEF = as.factor(DOSEF))
compute_grouped_mean_sd(
data_proc, deltaQTCF, NTLD, DOSE, reference_dose = 0
)
#> # A tibble: 30 × 17
#> # Groups: time [15]
#> time dose mean_dv sd geo_mean_dv geo_sd_dv n se ci_low ci_high
#> <dbl> <dbl> <dbl> <dbl> <lgl> <lgl> <int> <dbl> <dbl> <dbl>
#> 1 0.5 0 -8.28 6.43 NA NA 22 1.37 -11.1 -5.43
#> 2 0.5 120 -5.86 6.25 NA NA 21 1.36 -8.71 -3.02
#> 3 1 0 -5.43 7.06 NA NA 22 1.50 -8.55 -2.30
#> 4 1 120 -0.271 8.11 NA NA 21 1.77 -3.96 3.42
#> 5 1.5 0 -5.42 6.77 NA NA 22 1.44 -8.42 -2.41
#> 6 1.5 120 -4.20 8.35 NA NA 21 1.82 -8.00 -0.402
#> 7 2 0 -2.28 5.23 NA NA 22 1.11 -4.60 0.0352
#> 8 2 120 1.52 8.61 NA NA 21 1.88 -2.40 5.43
#> 9 2.5 0 -4.07 9.70 NA NA 22 2.07 -8.37 0.234
#> 10 2.5 120 1.01 10.4 NA NA 21 2.28 -3.74 5.76
#> # ℹ 20 more rows
#> # ℹ 7 more variables: group <chr>, mean_delta_dv <dbl>, geomean_delta_dv <int>,
#> # delta_sd <dbl>, delta_se <dbl>, ci_low_delta <dbl>, ci_up_delta <dbl>