C-QT analysis dataset for dofetilide with significant QTc effect (~38 ms prolongation)

C-QT analysis dataset for dofetilide with significant QTc effect (~38 ms prolongation)

cqtkit_data_dofetilide

Format

cqtkit_data_dofetilide

A tibble: 643 × 15:

ID

Uniuqe subject identifier

TRTG

Treatment Group (Drug or Placebo)

DOSE

numeric value of dose

DOSEU

Units of DOSE

DOSEF

Factor value of dose

NTLD

Nominal time since last dose (h)

CONC

Drug concentration

CONCU

Drug concentration unit

RR

RR after dose (ms)

RRBL

Baseline RR beore dose (ms)

HR

HR after dose (bpm)

HRBL

Baseline HR beore dose (ms)

HRBLM

Mean baseline HR across subjects (ms)

deltaHRBL

Difference between baseline HR and mean baseline HR across subjects (ms)

QT

QT after dose (ms)

QTBL

Baseline QT before dose (ms)

QTCB

Bazett's corrected QT after dose (ms)

QTCBBL

Baseline Bazett's corrected QT before dose (ms)

QTCBBLM

Mean baseline QTCB across subjects (ms)

deltaQTCBBL

Difference between baseline QTCB and mean baseline QTCB across subjects (ms)

QTCF

Fridericia's corrected QT after dose (ms)

QTCFBL

Baseline Fridericia's corrected QT before dose(ms)

QTCFBLM

Mean baseline QTCF across subjects (ms)

deltaQTCFBL

Difference between baseline QTCF and mean baseline QTCF across subjects (ms)

Source

Derived from Johannesen et. al. (https://ascpt.onlinelibrary.wiley.com/doi/10.1038/clpt.2014.155)