Generates pk parameters Cmax and Tmax for exporsure predictions.

Generates pk parameters Cmax and Tmax for exporsure predictions.

compute_pk_parameters(
  data,
  id_col,
  dose_col,
  conc_col,
  ntime_col,
  group_col = NULL
)

Arguments

data

A data frame containing C-QT analysis dataset

id_col

An unquoted column name for subject ID

dose_col

An unquoted column name for dose measurements

conc_col

An unquoted column name for drug concentration measurements

ntime_col

An unquoted column name for nominal times

group_col

An unquoted column name for additional grouping variable

Value

a dataframe of pk parameters

Examples

compute_pk_parameters(
  preprocess(cqtkit_data_verapamil) %>% dplyr::filter(DOSE != 0),
  ID,
  DOSE,
  CONC,
  NTLD)
#> # A tibble: 1 × 10
#>   group     N Tmax_median Tmax_max Tmax_min Cmax_gm Cmax_cv Cmax_median Cmax_max
#>   <dbl> <int>       <dbl>    <dbl>    <dbl>   <dbl>   <dbl>       <dbl>    <dbl>
#> 1   120    21           1        2      0.5    114.    57.0         102      368
#> # ℹ 1 more variable: Cmax_min <dbl>