Data from Age-Related Macular Degeneration (ARMD) clinical trial
armdA data frame with 867 rows and 8 columns:
A factor with 234 levels: 1, 2, 3, 4, 6, ..., 240
A factor with 2 levels: Placebo, Active
An integer vector with values ranging from 20 to 85
A factor with 8 levels: ----, ---X, --X-, --XX, -XX-, ..., X-XX
A factor with 4 levels: 4wks, 12wks, 24wks, 52wks
A numeric vector with values 4, 12, 24, 52
An integer vector with values ranging from 3 to 85
A numeric vector with values 1, 2, 3, 4 corresponding to time points 4, 12, 24, 52, respectively
Pharmacological Therapy for Macular Degeneration Study Group (1997). Interferon alpha-IIA is ineffective for patients with choroidal neovascularization secondary to age-related macular degeneration. Results of a prospective randomized placebo-controlled clinical trial. Archives of Ophthalmology, 115, 865-872.
The ARMD data arise from a randomized multi-center clinical trial comparing an experimental treatment (interferon-alpha) versus placebo for patients diagnosed with ARMD.
library(nlmeU)
data(armd)
summary(armd)
#> subject treat.f visual0 miss.pat time.f
#> 2 : 4 Placebo:451 Min. :20.0 ---- :752 4wks :231
#> 4 : 4 Active :416 1st Qu.:45.0 ---X : 72 12wks:227
#> 6 : 4 Median :56.0 --XX : 16 24wks:214
#> 7 : 4 Mean :54.9 --X- : 12 52wks:195
#> 8 : 4 3rd Qu.:66.0 -XXX : 6
#> 9 : 4 Max. :85.0 X--- : 6
#> (Other):843 (Other): 3
#> time visual tp
#> Min. : 4.00 Min. : 3.00 Min. :1.00
#> 1st Qu.: 4.00 1st Qu.:36.00 1st Qu.:1.00
#> Median :12.00 Median :50.00 Median :2.00
#> Mean :21.83 Mean :48.45 Mean :2.43
#> 3rd Qu.:24.00 3rd Qu.:62.00 3rd Qu.:3.00
#> Max. :52.00 Max. :85.00 Max. :4.00
#>