Example NONMEM Analysis-Ready Dataset for PK Modeling of a Single Ascending Dose Study

Example NONMEM Analysis-Ready Dataset for PK Modeling of a Single Ascending Dose Study

data_sad

Format

data.frame a data frame with 720 rows and 23 columns:

LINE

Line number

ID

NONMEM subject identifier

TIME

Actual time since first dose (units: hours)

NTIME

Nominal time since first dose (units: hours)

NDAY

Nominal study day (units: days)

DOSE

Nominal dose assignment (units: mg)

AMT

Actual dose amount administrered (units: mg)

EVID

NONMEM-specific event identifier

ODV

Dependent variable in original units (units: ng/mL)

LDV

Log-transformed dependent variable (units: log(ng/mL))

CMT

NONMEM-specific compartment variable (values: 1=dose, 2=plasma concentration)

MDV

NONMEM-specific missing dependent variable indicator

BLQ

Concentration below the lower limit of quantification flag (values: -1=pre-dose BLQ, 0=not BLQ, 1=post-dose BLQ)

LLOQ

Lower limit of quantification (units: ng/mL)

FOOD

Co-administration with food (values: 0=fasted, 1=high-fat meal)

SEXF

Subject of female sex (values: 0=male, 1=female)

RACE

Subject race (units: hours)

AGEBL

Subject age at baseline (units: years)

WTBL

Subject body weight at baseline (units:kg)

SCRBL

Subject serum creatinine at baseline (units: g/dL)

CRCLBL

Subject creatinine clearance at baseline (units: mL/min)

USUBJID

Study subject identifier

PART

Study part

...

Source

simulated